Ace Your PANCE Prep Pearls: 3rd Ed. (2019) Classes and Exams with Picmonic: #1 Visual Mnemonic Study Tool for Physician Assistant (PA) Students
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PANCE Prep Pearls: 3rd Ed. (2019) | Physician Assistant (PA) School Study Aid
Cyclophosphamide
- Mechanism
- Requires Bioactivation by Liver
- Cross-links DNA
- Guanine N7 Position
- Indications
- Autoimmune Disorders
- Leukemia
- Lymphoma
- Solid Tumors
- Side Effects
- Myelosuppression
- Hemorrhagic Cystitis
- Prevent with Mesna
3 mins
Cisplatin
- Indications
- Carcinomas
- Ovarian
- Bladder
- Lung
- Testicular
- Mechanism
- Cross-Links DNA
- Side Effects
- Ototoxicity
- Nephrotoxicity
- Treat with Amifostine and Chloride Diuresis
2 mins
Methotrexate
- Indications
- Rheumatoid Arthritis
- Cancer
- Medical Abortion
- Mechanism
- Folic Acid Analog
- Inhibits Dihydrofolate Reductase
- Side Effects
- Pulmonary Fibrosis
- Myelosuppression is Treated with Leucovorin Rescue (Folinic Acid)
- Macrocytic Anemia
- Hepatitis
- Teratogenic
- Mucositis
2 mins
Fluorouracil (5-FU)
- Mechanism
- Antimetabolite
- "Thymine-less Death"
- Indications
- Slow-growing Solid Tumors
- Co-administered with Leucovorin for Stomach Cancer
- Basal Cell Carcinoma (Topical)
- Side Effects
- Myelosuppression
- Mucositis
- Severe Diarrhea
3 mins
Paclitaxel (Taxanes)
- Mechanism of Action
- Taxane
- Stabilizes Microtubules
- Indications
- Breast Cancer
- Ovarian Cancer
- Non-Small Cell Lung Cancer
- Kaposi Sarcoma (HHV-8)
- Side Effects
- Mucositis
- Myelosuppression
- Peripheral Neuropathy
- Hypersensitivity
- Alopecia
- Considerations
- Diphenhydramine (Benadryl)
2 mins
Vincristine (Oncovin)
- Mechanism
- Vinca Alkaloid
- Inhibits Microtubules
- Indications
- Leukemias
- Lymphomas
- Side Effects
- Peripheral Neuropathy
- Paralytic Ileus
- Considerations
- Vesicant
2 mins
Doxorubicin (Adriamycin)
- Indications
- Solid Tumors
- Lymphomas and Leukemias
- Mechanism
- Free Radical Production
- Intercalates DNA
- Prevents Double Helix from Sealing
- Side Effect
- Cardiotoxicity
- Dexrazoxane Decreases Toxicity
1 min
Bleomycin
- Indications
- Testicular Cancer
- Hodgkin's Lymphoma
- Mechanism of Action
- Induces Free Radical Formation
- Breaks in DNA Strands
- Side Effects
- Pulmonary Fibrosis
- Skin Changes
- Mucositis
1 min
Hydroxyurea
- Mechanism
- Inhibits Ribonucleotide Reductase
- Decreased DNA Synthesis
- S-phase Specific
- Indications
- Melanoma
- Chronic Myelogenous Leukemia (CML)
- Sickle Cell Disease
- Through Increased HbF (Fetal Hemoglobin)
- Side Effects
- Myelosuppression
- GI Distress
2 mins
Rituximab
- Indications
- Chronic Lymphocytic Leukemia (CLL)
- Non-Hodgkin Lymphoma
- Rheumatoid Arthritis
- Microscopic Polyangiitis (MPA)
- Granulomatosis with Polyangiitis (Formerly Wegener's)
- Mechanism
- Monoclonal Antibody Against CD20
- Found on B Cell Neoplasms
- Side Effects
- Infusion Reactions
- Skin and Mouth Reactions
- Reactivation of Hepatitis B Virus (HBV)
- Progressive Multifocal Leukoencephalopathy (PML)
3 mins
