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Pathology | Physician Assistant (PA) School Study Aid
Diabetes Assessment
- Assessment Type 1
- Juvenile Onset
- Absent Insulin Production
- Ketosis Prone
- Assessment Type 2
- Adult Onset
- Insulin Resistance
- Obesity
- Gestational Diabetes
- Onset During Pregnancy
- Glucose Intolerance
- Complications
- Retinopathy
- Peripheral Vascular Disease
- Nephropathy
- Neuropathy
2 mins
Oral Glucose Tolerance Test (OGTT)
- Used for Diabetes Screening
- Fasting State
- Samples Drawn
- Baseline
- Normal < 100 mg/dL
- 30 and 60 Minutes
- Normal < 200 mg/dL
- 120 Minutes
- Normal < 140 mg/dL
2 mins
Diabetic Ketoacidosis (DKA) Signs and Symptoms
- Kussmaul respirations
- Dehydration
- Abdominal Pain
- Nausea/vomiting
- Psychosis
- Fruity breath Odor
1 min
Diabetic Ketoacidosis (DKA) Diagnosis and Labs
- Diagnosis
- Blood glucose Increased > 250 mg/dL
- Anion gap metabolic acidosis
- Decreased pH < 7.3
- Decreased serum bicarbonate < 18
- Plasma ketones
- Other Labs
- Hyperkalemia
1 min
Diabetic Ketoacidosis (DKA) Treatment
- Initial Management
- IV Normal Saline
- Regular Insulin Drip
- Subsequent Management (correction of electrolytes)
- Potassium (K+)
- Glucose
- Treat Underlying Cause
- Monitoring
- Venous pH
- Serum Bicarbonate (HCO3)
1 min
Diabetic Glomerulonephropathy
- Pathophysiology
- Nonenzymatic Glycosylation of Glomerular Basement Membrane
- Nonenzymatic Glycosylation of Arterioles
- Hyperfiltration
- Increased GFR
- Histological Findings
- Hyaline Arteriolosclerosis
- Mesangial Expansion
- Type IV Collagen Deposition
- Kimmelstiel Wilson Lesions
- Presentation
- Nephrotic
2 mins
Dawn Phenomenon
- Cause/Mechanism
- Increased Hormone Production
- Assessment
- Hyperglycemia Upon Awakening
- Interventions
- Long-Acting Evening Insulin
- Change Administration Times
- Insulin Pump
- Considerations
- Closely Monitor Glucose Levels
- Between 2-6AM
- Limit Carbohydrates Before Bedtime
2 mins
Corrected Na+ for Hyperglycemia
- Equation
- [(Glucose-100) * 0.016 ] + Na+
- Steps
- Glucose-100
- Multiply * 0.016
- Add Na+
1 min
Diabetes Education
- Self-Monitoring (Blood Glucose)
- SubQ Injection Technique
- Lifestyle Changes
- Symptoms of Hyperglycemia and Hypoglycemia
- Sick Day Care
- Foot Care
- Exercise Therapy
- Medication
1 min
Metabolic Syndrome
- Assessment
- Dyslipidemia
- Central Obesity
- Insulin Resistance
- Hypertension
- Increased C-Reactive Protein (CRP)
- Increased Fibrinogen
- Considerations
- Increased Risk Cardiovascular Disease
1 min
Gestational Diabetes
- Signs and Symptoms
- Usually Asymptomatic
- Fetal Macrosomia
- Polyhydramnios
- Diagnosis
- Glucose Intolerance After 24 Weeks Gestation
- 3-hr 100g Glucose Tolerance Test
- Treatment
- Diet and Exercise
- Close Glucose Monitoring
- Insulin
- Ultrasound (or Nonstress Test (NST))
- Delivery
2 mins
Acanthosis Nigricans
- Associations
- Endocrine Disorders
- Diabetes Mellitus
- Obesity
- Malignancy
- Presentation
- Velvety Plaques
- Dark, Thickened Flexural Areas
- Diagnosis
- Hyperkeratosis with Melanocytes
- Treatment
- Treat Underlying Disorder
2 mins
Hyperosmolar Hyperglycemic State
- Characteristics
- Insulin Present
- Increased Serum Osmolality
- Glucose >600 mg/dL
- No Significant Acidosis or Ketosis
- Clinical Features
- Severe Dehydration
- Altered Neurological Status
- Tachycardia and Hypotension
- Management
- IV Fluids
- Insulin
- Treat Underlying Disorder
3 mins
Nonproliferative Diabetic Retinopathy
- Characteristics
- Increased Capillary Permeability and Leakage
- Often Asymptomatic
- Fundoscopic Findings
- Retinal Microaneurysms
- Flame-shaped Hemorrhages
- Cotton Wool Spots
- Hard Exudates
- Macular Edema
- Management
- Treat Diabetes
- Laser Photocoagulation
- Bevacizumab
3 mins
Proliferative Diabetic Retinopathy
- Characteristics
- Angiogenesis
- Increased VEGF
- Asymptomatic Until Late-stage
- Fundoscopic Findings
- Vitreous Hemorrhage
- Retinal Detachment
- Glaucoma
- Findings of Nonproliferative Diabetic Retinopathy
- Management
- Laser Photocoagulation
- Surgery
- Bevacizumab
2 mins
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