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Pathology | Physician Assistant (PA) School Study Aid
Hyperbilirubinemia
- Cause/Mechanism
- Increased Unconjugated Bilirubin
- Assessment
- Jaundice
- Kernicterus
- Interventions
- Early Feedings
- Heme Oxygenase Inhibitors
- Phototherapy
- Protect Eyes
- Monitor for Dehydration
- Considerations
- Monitor Bilirubin Levels
3 mins
Primary Sclerosing Cholangitis Mechanisms
- Mechanism
- Unknown Mechanism
- "Onion Skin" Fibrosis
- "Beading" of Bile Ducts
- Symptoms
- Pruritus
- Hepatosplenomegaly
- Jaundice
2 mins
Primary Sclerosing Cholangitis Labs and Treatment
- Labs
- Increased Conjugated Bilirubin
- Increased ALK-P
- Increased IgM
- Associated Pathologies
- Ulcerative Colitis
- Cholangiocarcinoma
- Secondary Biliary Cirrhosis
- Treatment
- Liver Transplant
- Stent
2 mins
Primary Biliary Cholangitis (Primary Biliary Cirrhosis)
- Mechanism
- Autoimmune Destruction of Bile Ducts
- Intrahepatic bile ducts
- Cholestasis
- Occurs in Middle-Aged Females
- Signs and Symptoms
- Fatigue
- Pruritus
- Skin Hyperpigmentation
- Hepatomegaly
3 mins
Primary Biliary Cholangitis (Primary Biliary Cirrhosis) Diagnosis and Treatment
- Diagnosis
- Positive Antimitochondrial Antibodies
- Increased Alkaline Phosphatase (ALK-P)
- Increased Cholesterol
- Treatment
- Ursodiol
- Liver Transplant
2 mins
Clonorchis Sinensis
- Pathophysiology
- Trematode (Fluke)
- Undercooked Fish
- Biliary Tract Inflammation
- Pigmented Gallstones
- Associated with Cholangiocarcinoma
- Treatment
- Praziquantel
1 min
Cholecystitis Assessment
- RUQ Pain
- Referred Shoulder Pain
- Clay Colored Stools
- Jaundice
- Nausea and Vomiting
- Dyspepsia (Indigestion)
- Fever
- Considerations
- Increased WBCs
- Fatty or Spicy Foods
- Ultrasound
2 mins
Cholecystitis Causes
- Gallbladder Inflammation
- 6 Fs
- Female
- Fair (Caucasian)
- Fat (Obese)
- Fertile (Pregnant)
- Forty (Advanced Age Over 40)
- Flatulence
2 mins
Cholecystitis Interventions
- Supportive Therapy
- Antibiotics
- Low Fat Diet
- NG Tube
- Analgesics
- Lithotripsy
- Cholecystectomy
- T Tube
2 mins
Gallstones (Part 1/2)
- Characteristics
- Cholelithiasis
- Pathophysiology
- Increased Bilirubin
- Increased Cholesterol
- Stasis
- Decreased Bile Salts
- Risk Factors
- Cholesterol Stones are the Most Common Type
- Fat, Female, Fertile, Forty, Fair Complexion
- Crohn's Disease
- Rapid Weight Loss
- Estrogen Therapy
- Native American
- Diagnosis
- Ultrasound
- Treatment
- Cholecystectomy
3 mins
Gallstones (Part 2/2)
- Cholesterol Stones
- Cholesterol Stones are the Most Common Type
- Radiolucent
- Pigmented Stones
- Black Pigment Stones
- Hemolysis
- Brown Pigment Stones
- Infection
- Radiopaque
2 mins
Porcelain Gallbladder
- Characteristics
- Associated with Chronic Cholecystitis or Cholelithiasis
- Increased Risk of Gallbladder Adenocarcinoma
- Presentation
- RUQ Pain
- Usually Asymptomatic
- Often Found Incidentally
- Workup/Management
- Confirm with CT or Ultrasound
- Prophylactic Cholecystectomy
3 mins
Acute Cholangitis Characteristics and Clinical Features
- Characteristics
- Biliary Tract Infection
- Biliary Tract Obstruction
- Clinical Features
- Charcot's Triad
- Fever
- Jaundice
- Abdominal Pain
- Reynold's Pentad
- + Hypotension
- + Altered Mental Status
2 mins
Ascending Cholangitis Diagnosis and Treatment
- Imaging
- ERCP
- CT Scan
- Ultrasound
- Biliary Duct Dilation and/or Stones
- Labs
- Hyperbilirubinemia
- Elevated Alkaline Phosphatase
- Elevated GGT
- Treatment
- Broad Spectrum Antibiotics
- Biliary Drainage
4 mins
Bile
- Synthesis and Circulation
- Synthesized Continuously By Hepatocytes
- Cholesterol 7 Alpha-Hydroxylase Rate Limiting Step
- Stored In Gallbladder
- Secreted Into Duodenum
- Bile Salts Reabsorbed In Terminal Ileum
- Returned To Liver Via Portal Circulation
- Composition
- Bilirubin
- Bile Salts
- Cholesterol And Phospholipids
- Ions And Water
4 mins
Jaundice
- General
- Due To Elevated Conjugated Or Unconjugated Bilirubin
- Unconjugated
- Hemolysis
- Crigler-Najjar Or Gilbert's Syndrome
- Physiologic Jaundice Of Newborn
- Conjugated
- Biliary Obstruction From Stone Or Mass
- Cholangitis
- Dubin-Johnson And Rotor Syndrome
- Mixed
- Cirrhosis
- Hepatitis
5 mins
Biliary Atresia
- Cholestasis
- Unknown Etiology
- Symptoms
- Persistent Jaundice
- Acholic Stools
- Hepatomegaly
- Dark Urine
- Diagnosis
- Lab Values
- Ultrasound
- Treatment
- Kasai Procedure
- Liver Transplantation
- Complications
- Cirrhosis
- Portal Hypertension
3 mins
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