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Pathology | Physician Assistant (PA) School Study Aid
Gastroenteritis
- Cause/Mechanism
- Viruses
- Bacteria
- Food Intolerances
- Assessment
- Flu-Like Symptoms
- GI Distress
- Bloody Stool
- Interventions
- Oral Rehydration
- Considerations
- Self-Limiting
- Prevention
2 mins
Salmonella Typhi
- Characteristics
- Colonizes Gallbladder
- Monocytic Immune Response
- Symptoms
- Typhoid Fever
- Abdominal Pain
- Rose Spots on Abdomen
- Constipation Followed by Diarrhea
- Treatments
- Ceftriaxone
- Fluoroquinolones
- Considerations
- Oral Vaccine - Live
- IM Vaccine - Capsular Polysaccharide
2 mins
Clostridioides difficile (Clostridium difficile)
- Characteristics
- Gram-Positive
- Bacillus
- Anaerobe
- Clindamycin and Ampicillin
- Toxin A Enterotoxin
- Damages Brush Border of Gut
- Toxin B Cytotoxin
- Damages Cytoskeletal Structure
- Signs and Symptoms
- Diarrhea
- Pseudomembranous Colitis
- Toxic Megacolon
- Diagnosis
- Detect Toxins in Stool
- Treatment
- Metronidazole
- Vancomycin
3 mins
Clostridium difficile (Clostridioides difficile) Treatments
- Oral Vancomycin
- Fidaxomicin
- Metronidazole
- Stool Transplant
2 mins
E. coli Overview
- Characteristics
- Gram-Negative
- Bacillus
- Purple Colony with Metallic Green Sheen
- Lactose-Fermenting
- Pink on MacConkey Agar
- Disease
- Diarrhea
- Lipid A Septic Shock
- P Pili Pyelonephritis and Cystitis
- K Capsule Neonatal Meningitis
- K Capsule Pneumonia
- H Antigen Flagella
2 mins
Enterohemorrhagic E. Coli (EHEC)
- Characteristics
- O157:H7
- Non-Sorbitol Fermenting
- Hamburger Meat
- Produces Shiga-like Toxin
- Gram-negative
- Lysogeny
- Inactivates 60S Ribosome
- Disease
- Bloody Diarrhea
- Hemolytic Uremic Syndrome (HUS)
- Hemolytic Anemia
- Acute Renal Failure
- Thrombocytopenia
2 mins
Shigella
- Characteristics
- Gram-Negative
- Bacilli
- Non Lactose Fermenting
- White on Macconkey Agar
- Oxidase Negative
- Non H2S Producing
- Day Care Centers
- High Virulence
- Replicates Intracellularly
- Actin Rocket
- Signs and Symptoms
- Bloody Diarrhea
- Shiga Toxin
- Inhibits 60S Ribosome
- Hemolytic Uremic Syndrome (HUS)
- Hemolytic Anemia
- Thrombocytopenia
- Kidney Failure
3 mins
Listeria Monocytogenes Characteristics
- Characteristics
- Gram Positive
- Bacillus
- Intracellular
- Survives in Cold Temperature
- Actin Rocket
- Tumbling Motility
- Catalase-Positive
- Beta-Hemolytic
- Only Gram-Positive with Endotoxin-Like Structure
2 mins
Listeria Monocytogenes Disease
- Signs and Symptoms
- Soft Cheese
- Pregnant Women Have Flu-Like Symptoms
- Pregnant Women Have GI Symptoms
- Granulomatosis Infantiseptica
- Spontaneous Abortion
- Meningitis
- Monocytes in CSF
- Treatment
- Ampicillin
2 mins
Norovirus
- Characteristics
- Calicivirus
- RNA Virus
- Non-enveloped
- Icosahedral
- SS Positive Linear
- Symptoms
- Acute Gastroenteritis
- Treatment
- Supportive Therapy
- Considerations
- Often found in Cruise Ships
1 min
Rotavirus
- Characteristics
- Reovirus
- Non-enveloped
- Double-Stranded
- RNA Virus
- Linear
- 11 Segments
- Triple Icosahedral Capsid
- Most Common Cause of Diarrhea Worldwide
- Villous Atrophy
- Winter Months
- Day Care Centers
- Treatment
- Oral Rehydration
2 mins
Hepatitis A
- Characteristics
- Picornavirus
- 4 Week Incubation Period
- Fecal-oral
- Day Care Centers
- Travel to Developing Countries
- Signs and Symptoms
- Usually Asymptomatic
- Acute Disease
- Jaundice
- Fever
- Vomiting
2 mins
Hepatitis A (HAV) Assessment
- Transmission
- Fecal-Oral
- Ingestion of Contaminated Food or Water
- Incubation
- 4 Weeks
- Assessment
- Fever
- General Malaise
- Hepatomegaly
- Considerations
- Self-Limiting
- Proper Hand Washing
2 mins
Hepatitis B Virus Disease
- Can turn chronic
- < 10% of adults become chronic carriers
- 90% of newborns become chronic carriers
- Cirrhosis
- Hepatocellular carcinoma
- Membranous Glomerulonephritis
- Polyarteritis nodosa
- Serum sickness like syndrome
2 mins
Hepatitis B (HBV) Assessment
- Transmission
- Bodily Fluids
- Blood Transmission
- People Who Use IV Drugs
- Incubation
- Variable 1-6 Months
- Assessment
- Fever
- Nausea and Vomiting
- Hepatomegaly
- Chronic Disease
- Cirrhosis
- Hepatocellular Carcinoma
- Considerations
- Vaccination
2 mins
Hepatitis B Virus Characteristics
- Hepadnavirus
- Enveloped
- Circular
- Partially Double-stranded DNA
- Has Reverse Transcriptase
- IV Drug Use
- Sex
- Maternal Fetal Routes
- 3 Month Incubation Period
2 mins
Hepatitis C
- Characteristics
- Enveloped
- RNA Virus
- Flavivirus
- Icosahedral
- SS positive Linear
- Clinical Features
- Most Cases are Due to IV Drug Use
- Turns to Chronic Hepatitis in Over 70% of Cases
- Cirrhosis
- Hepatocellular Carcinoma
- Most Common Indication for Liver Transplantation
- Associated With Type I MPGN
- Porphyria Cutanea Tarda
2 mins
Hepatitis C (HCV) Assessment
- Transmission
- Blood Transmission
- High Risk Sex (rare)
- IV Drug Users
- Incubation
- 7 Weeks
- Chronic Disease
- Cirrhosis
- Considerations
- Barrier Protection
2 mins
Clostridium botulinum
- Characteristics
- Bacillus
- Gram-positive
- Anaerobe
- Spore-forming
- Heat Labile Toxin
- Inhibits Acetylcholine (Ach) Release at Neuromuscular Junction (NMJ)
- Canned Food in Adults
- Spores in Honey
- Signs and Symptoms
- Descending Flaccid Paralysis
- Diplopia
- Ptosis
- Floppy Baby
- Constipation
2 mins
Staphylococcus aureus Disease
- Skin Infections
- Impetigo
- Abscesses
- Exfoliative Toxin
- Scalded Skin Syndrome
- Toxic Shock Syndrome (TSST 1)
- Binds to MHC II and T Cell Receptor
- Food Poisoning
- Acute Bacterial Endocarditis
- Pneumonia
- Osteomyelitis
2 mins
Bacillus Cereus Characteristics
- Gram-Positive
- Bacilli
- Endospore Forming
- B Hemolytic
- Toxins and Enterotoxins
- Reheated Rice
1 min
Bacillus Cereus Disease
- Signs and Symptoms
- Emetic Form
- Short Incubation (1-6 Hours)
- Nausea and Vomiting
- Diarrheal Form
- Long Incubation (8-16 Hours)
- Diarrhea and GI Pain
2 mins
Entamoeba histolytica
- Pathophysiology
- Protozoa
- Amebiasis
- Ingestion of Cysts in Food and Water
- Signs and Symptoms
- Bloody Diarrhea
- Flask-Shaped Ulcer
- Liver Abscess
- Anchovy Paste
- RUQ Pain
- Diagnosis
- RBCs in Cytoplasm of Trophozoite
- Cyst With Four Nuclei
- Treatment
- Metronidazole
- Iodoquinol
3 mins
Giardia lamblia
- Characteristics
- Protozoa
- Ingestion of Cysts
- Seen in Campers
- Daycare Centers
- Mental Hospitals
- Infects Small Intestine
- Signs and Symptoms
- Bloating
- Flatulence
- Fatty Diarrhea
- Diagnosis
- Crescent-shaped Protozoa Adjacent to Epithelial Brush Border
- Predisposed if Low IgA
- Treatment
- Metronidazole
3 mins
Echinococcus Granulosus
- Pathophysiology
- Cestode (Tapeworm)
- Ingestion of Eggs from Dog Feces
- Hydatid Cysts in Liver
- Fibrosis and Necrosis
- Anaphylaxis if Antigens Released
- Treatment
- Albendazole
- Surgical Removal
1 min
Trypanosoma cruzi
- Pathophysiology
- Protozoa
- Triatomine Bug
- Kissing bug
- Painless bite
- Predominantly in South America
- Symptoms
- Chagas disease
- Romana's sign
- Dilated Cardiomyopathy
- Megacolon
- Megaesophagus
- Diagnosis
- Blood smear
- Treatment
- Nifurtimox
- Benznidazole
2 mins
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