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Pathology | Physician Assistant (PA) School Study Aid
Varicocele
- Pathophysiology
- Dilation of Pampiniform Plexus Veins
- Signs and Symptoms
- Soft Left-Sided Scrotal Mass
- Bag of Worms
- Increased Size with Standing or Valsalva
- Decreased Size while Supine
- Testicular Atrophy
- Subfertility
- Diagnosis
- Ultrasound
- Retrograde Venous Flow
- Treatment
- Surgical Gonadal Vein Ligation
- Scrotal Support
3 mins
Hydrocele
- Mechanism
- Impaired Lymphatic Drainage
- Signs and Symptoms
- Large Scrotum
- Painless
- Considerations
- Needle Aspiration or Surgery
- Scrotal Support
- Monitor for Bleeding and Infection
1 min
Erectile Dysfunction
- Cause/Mechanism
- Age-Related Changes
- Psychological
- Medical Conditions
- Drug-Induced
- Assessment
- Sexual Dysfunction (Unable to Maintain Erection)
- Interventions
- Phosphodiesterase Type 5 (PDE5) Inhibitors
- Vacuum Constriction Devices
- Intraurethral Devices
- Penile Implants
- Considerations
- Sexual Counseling
2 mins
Liddle Syndrome
- Pathophysiology
- Autosomal Dominant
- Collecting Duct
- Gain of Function Mutation in Epithelial Sodium Channel (ENaC)
- Excess Na+ and H2O Reabsorption
- Clinical Features
- Decreased Renin
- Decreased Aldosterone
- Hypertension with Hypokalemia
- Metabolic Alkalosis
- Pseudohyperaldosteronism
- Treatment
- Amiloride and Triamterene
3 mins
Gitelman Syndrome
- Pathophysiology
- Autosomal Recessive
- Defective Sodium-Chloride Cotransporter in Distal Tubule
- Mechanism Mimics Thiazide Diuretics
- Clinical Presentation
- Cramping and Tetany
- Severe Fatigue
- Polyuria
- Diagnosis
- Hypokalemia
- Metabolic Alkalosis
- High Urine Chloride
- Treatment
- Electrolyte Supplements
- Spironolactone
4 mins
Syndrome Of Apparent Mineralocorticoid Excess (SAME)
- Pathophysiology
- 11 Beta-Hydroxysteroid Dehydrogenase Deficiency
- Elevated Cortisol
- Low Renin
- Low Aldosterone
- Causes
- Autosomal-Recessive
- Licorice (glycyrrhetinic acid) Ingestion
- Signs & Symptoms
- Hypertension
- Hypokalemia
- Metabolic Alkalosis
- Treatment
- Potassium-Sparing Diuretics
4 mins
Testicular Torsion
- Characteristics
- Sudden Twisting of Spermatic Cord
- Affects Neonates and Adolescents
- Bell Clapper Deformity
- Clinical Features
- Severe Acute Testicular Pain
- Abnormal Testicular Position
- Nausea and Vomiting
- Diagnosis
- Doppler Ultrasound of the Scrotum
- Treatment
- Emergent Surgical Intervention
- Manual Detorsion
- Considerations
- Testicular Infarction
- Infertility in Males
4 mins
Bartter Syndrome
- Pathophysiology
- Autosomal Recessive
- Thick Ascending Limb of Loop of Henle
- Defective NKCC Cotransporter
- Decreased Na+ Reabsorption
- Decreased Ca2+ Reabsorption
- Increased Aldosterone
- Clinical Features
- Hypovolemia
- Polyuria and Polydipsia
- Metabolic Alkalosis
- Mimics Loop Diuretics
- Nephrolithiasis
- Treatment
- Spironolactone (Aldactone)
4 mins
Prerenal Acute Kidney Injury Pathophysiology and Presentation
- Pathophysiology
- Decreased Renal Perfusion
- Decreased GFR
- Increased Sodium and Water Reabsorption
- Presentation
- Edema
- Dyspnea
- Hypotension with Tachycardia
- Altered Mental Status
- Oliguria
- Etiologies
- NSAIDs
- Renal Artery Stenosis
- ACE Inhibitors
2 mins
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