Ace Your First Aid for the USMLE Step 2 CK (10th Ed.) Classes and Exams with Picmonic: #1 Visual Mnemonic Study Tool for Medicine (MD/DO) Students
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First Aid for the USMLE Step 2 CK (10th Ed.) | Medicine (MD/DO) School Study Aid
Bruton's Agammaglobulinemia
- Pathophysiology
- X-linked Recessive
- Defective Bruton Tyrosine Kinase
- Blocks B Cell Maturation
- Signs & Symptoms
- Decreased Immunoglobulins of All Classes
- Bacterial Infections After Six Months
- Maternal IgG Protects Before Six Months
2 mins
Complement Disorders
- Early Complement Deficiency
- Pyogenic Infections
- SLE
- Sinus Infections
- Terminal Complement Deficiency
- Autosomal Recessive
- Neisseria Infections
- C5-C9
- MAC (Membrane Attack Complex)
4 mins
Common Variable Immunodeficiency
- Pathophysiology
- Defect in B Cell Maturation
- Decreased Plasma Cells
- Decreased Immunoglobulins
- Signs & Symptoms
- Sinopulmonary Infections
- Increased Risk of Autoimmune Disease
- Lymphoma
1 min
Severe Combined Immunodeficiency (SCID)
- Both B and T Cell Deficiency
- Recurrent Viral, Bacterial, Fungal, Protozoal Infections
- Defective Interleukin (IL) 2 Receptor
- X-Linked
- Adenosine Deaminase Deficiency
- Failure to Synthesize MHC II Antigens
- Treat with Bone Marrow Transplant
2 mins
Selective IgA Deficiency
- Pathophysiology
- Defect in Class Switching
- Decreased IgA
- Signs and Symptoms
- Often Asymptomatic
- Increase in Atopic & Autoimmune Diseases
- Sinopulmonary Infections
- Increased Risk Giardia Lamblia Infections
- Inflammatory Bowel Disease
- Celiac Disease
- Considerations
- Anaphylaxis From IgA Containing Blood Products
2 mins
Hyper IgM Syndrome
- Pathophysiology
- Deficient CD40 Ligand on Helper T-cells
- Defective CD40 Receptor on B-cells
- Inability to Class Switch
- Signs and Symptoms
- Pyogenic Abscess
- Decreased IgG, IgA, IgE
4 mins
Thymic Aplasia (DiGeorge Syndrome)
- Pathophysiology
- DiGeorge Syndrome
- 22q11 Deletion
- Failure to Develop Third and Fourth Pharyngeal Pouches
- Signs and Symptoms
- Undeveloped Thymus
- T Cell Deficiency
- Recurrent Viral and Fungal Infections
- Undeveloped Parathyroids
- Hypocalcemia
- Tetany
- Aortic Defects
- Congenital Heart Defects
- Diagnosis
- Absent Thymic Shadow on CXR
2 mins
Ataxia Telangiectasia
- Pathophysiology
- Autosomal Recessive
- ATM Gene
- Defect in DNA repair
- Signs & Symptoms
- Cerebellar defects
- Spider Angiomas
- Sensitive to Radiation
- Defective Tumor Suppressor Gene
- Increased risk of Cancer, Leukemias, and Lymphomas
- Increased AFP levels
- IgA deficiency
- Repeated sinopulmonary infections
2 mins
Wiskott Aldrich
- Pathophysiology
- X-linked Recessive
- WASp Protein Mutation
- Antigen Presentation Defect
- Progressive Deletion of B and T Cells
- Signs and Symptoms
- Thrombocytopenia
- Eczema
- Infections
- Decreased IgM
- Increased IgE, IgA
2 mins
Chronic Granulomatous Disease
- Pathophysiology
- Most Commonly X-linked Recessive
- Defective NADPH Oxidase (Enzyme Complex)
- Decreased Hydrogen Peroxide
- Impaired Intracellular Killing in Phagocytes
- Signs and Symptoms
- Recurrent Purulent Skin and Lung Infections
- Catalase Positive Organisms
- Diagnosis
- Negative Nitroblue Tetrazolium Test
- DHR (Dihydrorhodamine) Flow Cytometry
- Treatment
- Antimicrobial Prophylaxis
- TMP-SMX
- Itraconazole
- Interferon-Gamma
3 mins
Leukocyte Adhesion Deficiency
- Pathophysiology
- Autosomal Recessive
- Integrin CD18 Protein
- Defect in LFA-1
- Attached to ICAM
- Signs and Symptoms
- Neutrophilia
- Bacterial Infections
- Non-Pyogenic
- Delayed Separation of Umbilical Cord
2 mins
Chediak-Higashi Syndrome
- Pathophysiology
- Autosomal Recessive
- Defective Lysosomal Trafficking Regulator Gene (LYST)
- Defect In Microtubular Function
- Decrease In Phagocytosis
- Signs And Symptoms
- Recurrent Pyogenic Infections
- Staph Aureus And Streptococci
- Partial Albinism
- Peripheral Neuropathy
- Pancytopenia
- Diagnosis
- Giant Granules In Granulocytes And Platelets
2 mins
Hyper IgE Syndrome
- Job Syndrome (Autosomal Dominant Hyper IgE Syndrome)
- Pathophysiology
- Autosomal Dominant
- STAT3 Mutation
- Increased IgE
- Abnormal Chemotaxis
- Signs and Symptoms
- Leonine Facies
- Cold (Non-Inflamed) Staph Aureus Abscesses
- Retained Primary Teeth
- Eczema
- Management
- Prophylactic Antibiotics
2 mins
C1 Esterase Inhibitor Deficiency
- Pathophysiology
- Autosomal Dominant
- Disinhibition of Kallikrein
- Increased Bradykinin
- Decreased C4
- Clinical Features
- Recurrent Angioedema
- Upper Airway Obstruction
- Considerations
- ACE Inhibitors Contraindicated
- Avoid Triggers
3 mins
Kawasaki Disease
- Pathophysiology
- Prevalent in Asian Children
- Necrotizing Vasculitis
- Signs and Symptoms
- Fever
- Strawberry-Red Tongue and Mucosa
- Lymphadenopathy
- Desquamative Skin Rash
- Erythema and Edema of the Hands and Feet
- Conjunctivitis
- Coronary Aneurysm
- Treatment
- Intravenous Immunoglobulin (IVIG)
- Aspirin
2 mins
Systemic Juvenile Idiopathic Arthritis Characteristics and Presentation
- Characteristics
- Idiopathic
- Still's Disease
- Autoimmune Joint Destruction
- Onset < 16 Years Old
- Presentation
- Arthritis
- Quotidian Fever
- Evanescent Exanthem
- Lymphadenopathy
- Hepatosplenomegaly
2 mins
Systemic Juvenile Idiopathic Arthritis Diagnosis and Management
- Laboratory Findings
- Increased Ferritin
- Management
- Glucocorticoids
- Tocilizumab
- Anakinra
- Complications
- Joint Deformities
- Limb-Length Discrepancy
- Uveitis
- Macrophage Activation Syndrome
- Considerations
- Variable Prognosis
2 mins
Hemophagocytic Lymphohistiocytosis
- Characteristics
- Excessive Immune System Activation
- Cytotoxic T-cells and Macrophages
- Cytokine Storm
- Acquired or Sporadic
- Presentation
- Fever
- Hepatosplenomegaly
- Labs
- Increased Ferritin
- Pancytopenia
- Management
- Bone Marrow Transplantation
3 mins
